. 2023 Dec 18;11(12):3343. doi: 10.3390/biomedicines11123343

Table 1.

Recommendations for monitoring patients with hereditary forms of pancreatic cancer and melanoma.

Melanoma	Pancreatic Cancer
Self-examination of the skin: Regularly check for the emergence of new nevi or any changes in the appearance of existing ones. Inspect existing nevi: keep a vigilant eye on existing nevi to monitor alterations in their shape, size, and color. Biannual dermatologist examinations: Schedule visits with a dermatologist twice a year. This includes the mapping of moles, followed by a dermatoscopy for a detailed examination. In case of suspected melanoma, consider the scraping of nevi followed by cytological examination. Sun protection for high-risk individuals: Individuals with familial melanoma and carrying pathogenic mutations in the CDKN2A gene, who have an elevated risk of melanoma, should regularly use sunscreens and take measures to avoid direct skin exposure to sunlight. Early screening for children in high-risk families: Initiate screening procedures and melanoma diagnosis for children in families with identified cases of melanoma from the age of 10.	Screening at age 40 (or 10 years earlier than earliest family diagnosis): Begin screening for pancreatic cancer at the age of 40, or 10 years prior to the earliest diagnosis of pancreatic cancer in the family history. Annual MRI with contrast: Undergo an MRI with contrast once a year, starting between the ages of 30 and 35. Endoscopic ultrasound examination: Consider an endoscopic ultrasound examination for a detailed assessment of the pancreas.

Melanoma

Pancreatic Cancer

Self-examination of the skin:
Regularly check for the emergence of new nevi or any changes in the appearance of existing ones. Inspect existing nevi: keep a vigilant eye on existing nevi to monitor alterations in their shape, size, and color.

Biannual dermatologist examinations: Schedule visits with a dermatologist twice a year. This includes the mapping of moles, followed by a dermatoscopy for a detailed examination. In case of suspected melanoma, consider the scraping of nevi followed by cytological examination.

Sun protection for high-risk individuals: Individuals with familial melanoma and carrying pathogenic mutations in the CDKN2A gene, who have an elevated risk of melanoma, should regularly use sunscreens and take measures to avoid direct skin exposure to sunlight.

Early screening for children in high-risk families:
Initiate screening procedures and melanoma diagnosis for children in families with identified cases of melanoma from the age of 10.

Screening at age 40 (or 10 years earlier than earliest family diagnosis): Begin screening for pancreatic cancer at the age of 40, or 10 years prior to the earliest diagnosis of pancreatic cancer in the family history.

Annual MRI with contrast: Undergo an MRI with contrast once a year, starting between the ages of 30 and 35.

Endoscopic ultrasound examination: Consider an endoscopic ultrasound examination for a detailed assessment of the pancreas.