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. 2023 Dec 7;15(24):5742. doi: 10.3390/cancers15245742
GC Gastric cancer
CLDN 18.2 Claudin 18 isoform 2
AGC Advanced GC
GC Gastric cancer
GEJ Gastroesophageal junction
G/GEJ Gastric/ Gastroesophageal junction
HER2 Epidermal growth factor receptor 2
CLDN Claudin
OS Overall survival
LAST 1/2 Large tumor suppressor kinase 1/2
YAP1 Yes-associated protein 1
ICI Immune checkpoint inhibitor
mAb Monoclonal antibody
PD-1 Programmed cell death-1
GS Genomically stable
IHC Immunohistochemistry
PD-L1 Programmed cell death-ligand 1
dMMR Deficient mismatch repair
MSI Microsatellite instability
FGFR2 Fibroblast growth factor receptor 2
EBV Epstein–Barr virus
CPS Combined positive score
BsAbs Bispecific antibodies
CAR Chimeric antigen receptor
ADC Antibody–drug conjugates
IgG1 Immunoglobulin G1
ADCC Antibody-dependent cellular cytotoxicity
CDC Complement-dependent cytotoxicity
ADCP Antibody-dependent cellular phagocytosis
DLT Dose-limiting toxicity
AE Adverse event
TRAEs Treatment-related AEs
PK Pharmacokinetics
PD Pharmacodynamics
ORR Objective response rate
DCR Disease control rate
PFS Progression-free survival
DoR Duration of response
mFOLFOX  Modified FOLFOX (5-FU + Leucovorin + Oxaliplatin)
EOX Epirubicin + Oxaliplatin + Capecitabine
HR Hazard ratio
CI Confidence interval
CAPOX Capecitabine + Oxaliplatin
CR Complete response
PR Partial Response
SD Stable disease
FcγRIIIa CD16a
mRNA Messenger ribonucleic acid
RP2D Recommended phase II dose
MTD Maximum tolerated dose
VHH Variable domain of Heavy chain of Heavy chain
CDX Cell-derived xenograft
PDX Patient-derived xenograft
NK Natural killer
DCs Dendritic cells
BiTE Bispecific T-cell engager
AT-BOIN Accelerated titration-Bayesian optimal interval
TAA Tumor-associated antigen
MMAE Monomethyl auristatin E
Q3W Once-every-3-weeks
CRS Cytokine release syndrome
DNA Deoxyribonucleic acid
NKD2G Natural killer group 2, member D
TAC T-cell antigen coupler
mRNA Messenger RNA
RNase Ribonuclease
LNPs Lipid nanoparticles