Table 1.
Demographic, motor, and functional data within HD stages: +: higher scores = better performance; #: higher scores = more impairment. Abbreviations: CAG: cytosine-adenine-guanine repeat length; ISCED, International Standard Classification of Education—educational level; CAP score: CAG-age product—index; HD: Huntington’s disease; TMS: Total Motor Score; TFC: Total Functional Capacity; y: years. SDMT, Symbol Digit Modalities test; VFc, verbal fluency test (category); SCNT, Stroop color naming test; SWRT, Stroop word reading test; SIT, Stroop interference test.
| HD Stage 1 n = 3319 |
HD Stage 2 n = 3580 |
HD Stage 3 n = 2296 |
HD Stage 4 n = 809 |
HD Stage 5 n = 310 |
F | p | Part. Eta2 | |
|---|---|---|---|---|---|---|---|---|
| Age (y); M (SD) | 50.30 (11.95) | 52.86 (12.49) | 54.48 (12.82) | 56.53 (12.85) | 58.17 (13.95) | 68.93 | <0.001 | 0.026 |
| CAG; M(SD) | 43.73 (3.43) | 43.92 (3.87) | 44.40 (4.31) | 44.69 (4.37) | 45.63 (4.55) | 33.27 | <0.001 | 0.013 |
| Sex (f/m) (%f) | 1513/1806 (45.6) | 1891/1689 (52.8) | 1249/1047 (54.4) | 465/344 (57.5) | 183/127 (59.0) | 75.27 | <0.001 | 0.004 |
| ISCED; M (SD) | 3.67 (1.19) | 3.43 (1.20) | 3.21 (1.25) | 2.97 (1.24) | 2.84 (1.29) | 93.97 | <0.001 | 0.035 |
| CAP-Score; M (SD) | 475.53 (78.31) | 507.03 (87.63) | 548.37 (92.99) | 587.65 (98.79) | 632.34 (128.66) | 523.96 | <0.001 | 0.169 |
| Disease duration (y); M (SD) | 4.90 (6.33) | 6.75 (5.62) | 9.18 (6.69) | 12.87 (8.76) | 19.19 (14.45) | 522.51 | <0.001 | 0.169 |
| HD Diagnosis (y); M (SD) | 48.68 (12.09) | 49.63 (12.75) | 49.41 (13.22) | 48.39 (13.77) | 46.14 (13.17) | 6.97 | <0.001 | 0.003 |
| Motor Onset (y); M (SD) | 46.29 (11.79) | 46.77 (12.27) | 46.31 (12.78) | 45.15 (13.43) | 42.10 (12.94) | 10.91 | <0.001 | 0.004 |
| TMS; M (SD) # | 23.84 (11.31) | 35.62 (14.00) | 50.51 (17.10) | 69.54 (17.33) | 85.82 (16.24) | 3056.04 | <0.001 | 0.544 |
| SDMT + | 30.49 (11.01) (n = 3278) |
22.19 (9.5) (n = 3470) |
14.32 (8.91) (n = 1959) |
5.45 (6.60) (n = 510) |
0.97 (3.16) (n = 156) |
1458.27 | <0.001 | 0.384 |
| VFc + | 15.29 (5.20) (n = 3286) |
12.12 (4.66) (n = 3537) |
8.73 (4.31) (n = 2225) |
5.32 (3.57) (n = 680) |
1.77 (2.65) (n = 189) |
124.97 | <0.001 | 0.334 |
| SCNT + | 51.93 (14.10) (n = 3272) |
42.02 (13.67) (n = 3512) |
30.96 (13.37) (n = 2172) |
18.82 (12.85) (n = 638) |
5.94 (9.92) (n = 184) |
1549.98 | <0.001 | 0.388 |
| SWRT + | 69.91 (18.30) (n = 3281) |
55.51 (17.61) (n = 3497) |
41.27 (17.92) (n = 2140) |
24.39 (17.44) (n = 626) |
6.79 (12.31) (n = 181) |
1682.56 | <0.001 | 0.409 |
| SIT + | 28.92 (10.04) (n = 3038) |
22.82 (9.70) (n = 3128) |
15.96 (9.10) (n = 1721) |
9.29 (7.76) (n = 423) |
4.07 (6.65) (n = 74) |
808.67 | <0.001 | 0.279 |