Table 2.
Comparison of neuropsychiatric data between different HD stages: #: higher scores = more impairment.
| HD Stage 1 n = 3319 |
HD Stage 2 n = 3580 |
HD Stage 3 n = 2296 |
HD Stage 4 n = 809 |
HD Stage 5 n = 310 |
F | p | Part. Eta2 | |
|---|---|---|---|---|---|---|---|---|
| Clinical rater (PBA-s) | ||||||||
| Depression; M (SD) # |
4.63 (5.81) (n = 3315) |
5.66 (6.65) (n = 3571) |
5.51 (6.90) (n = 2278) |
5.05 (6.30) (n = 775) |
4.53 (5.77) (n = 205) |
13.241 | <0.001 | 0.005 |
| Irritability; M (SD) # |
2.62 (3.99) | 3.40 (4.82) | 3.83 (5.63) | 4.53 (6.42) | 5.04 (6.65) | 42.44 | <0.001 | 0.016 |
| Psychosis; M (SD) # |
0.14 (1.10) | 0.31 (1.61) | 0.50 (2.22) | 0.86 (3.21) | 0.61 (2.03) | 31.74 | <0.001 | 0.012 |
| Apathy; M (SD) # |
1.76 (3.03) | 3.24 (3.93) | 5.12 (4.96) | 6.71 (5.86) | 8.11 (6.47) | 411.00 | <0.001 | 0.139 |
| Executive function; M (SD) # |
1.97 (3.76) | 3.33 (5.04) | 5.01 (6.25) | 6.69 (7.41) | 5.84 (7.04) | 199.82 | <0.001 | 0.073 |
| Self-report (HADS-IS) | ||||||||
| Anxiety; M (SD) # | 5.76 (4.08) (n = 2055) |
6.20 (4.31) (n = 2116) |
6.09 (4.31) (n = 1093) |
6.12 (4.34) (n = 269) |
5.84 (4.54) (n = 46) |
3.00 | 0.018 | 0.002 |
| Depression; M (SD) # |
4.95 (3.78) | 6.38 (4.05) | 7.30 (4.39) | 8.32 (4.92) | 9.22 (4.75) | 93.28 | <0.001 | 0.063 |
| Irritability; M (SD) # |
5.77 (4.39) | 6.24 (4.76) | 5.95 (4.73) | 5.62 (4.62) | 5.42 (4.01) | 3.31 | <0.001 | 0.002 |
| Outward irritability; M (SD) # |
3.47 (2.64) | 3.73 (2.88) | 3.65 (2.94) | 3.58 (3.08) | 3.43 (2.60) | 2.45 | 0.044 | 0.002 |
| Inward irritability; M (SD) # |
2.31 (2.35) | 2.51 (2.54) | 2.31 (2.58) | 2.06 (2.39) | 2.07 (2.24) | 3.30 | 0.011 | 0.002 |