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. 2023 Dec 8;15(24):5753. doi: 10.3390/cancers15245753

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of treatment responses in subcutaneous and orthotopic settings. (A) Tissue samples of the PDAC PDX model Panc12529 were transplanted orthotopically, receiving the above-mentioned treatment regimen. Measurement of tumor volumes in the orthotopic setting by using ultrasound measurements of tumors (T) within the pancreas of mice and respective calculation of tumor volumes with software VevoLAB 2.2.0. (B) The resulting tumor volumes in both settings are given as mean tumor volumes + SD.