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(A) ΔS scores for compounds targeting non-RAS proteins and reportedly binding or associated with neurofibromin. PTK2 (focal adhesion protein, FAK), TUBB (tubulin), LIMK1 (LIM Domain Kinase 1), and ALK (anaplastic lymphoma kinase). (B) Concentration–response curves for NVP-TAE226, an inhibitor of FAK, and (C) demecolcine, an inhibitor of tubulin. Lines in purple indicated data from the reference cell line ipnNF95.11C.
