Table 1.
Description of immortalized human cell lines used in the study.
| Human Cell Lines | |||
|---|---|---|---|
| Cell Line | Immortalized | Tissue Source | Neurofibromin Status |
| ipnNF95.11C * | yes | Peripheral nerve (non-tumor) | +/− |
| ipNF06.2A | yes | Plexiform Neurofibroma (PNF1) | −/− |
| ipNF95.6 * | yes | Plexiform Neurofibroma (PNF1) | −/− |
| ipNF95.11b C/T | yes | Plexiform Neurofibroma (PNF1) | −/− |
| ipNF05.5 Mixed Clone (ipNF05.5-MX) |
yes | Plexiform Neurofibroma (PNF1) | −/− |
* A recent analysis (M.R. Wallace, personal communication) has suggested that the cell lines ipnNF95.11C and ipNF95.6 may consist of a mixed population of homozygous NF1−/− and heterozygous NF1+/− cells, although the initial testing [15,16] reported them as in the table above and we analyzed them as such.