Table 7.
Association of curcumin and gentamicin against P. aeruginosa bacterial strain.
| Strain | Compound | MIC Alone | Antimicrobial Activity in Combination (CUR and GEN) | FICI | Interaction * |
|---|---|---|---|---|---|
| Pseudomonas aeruginosa | CUR | 5.5 µg/mL | 28.7 µg/mL and 0.06 µg/mL | 1 | Additivity |
| 28.7 µg/mL and 0.03 µg/mL | 0.75 | Additivity | |||
| GEN | 0.12 µg/mL | 28.7 µg/mL and 0.02 µg/mL | 0.62 | Additivity | |
| 14.4 µg/mL and 0.06 µg/mL | 0.75 | Additivity | |||
| 7.2 µg/mL and 0.06 µg/mL | 0.62 | Additivity | |||
| 3.6 µg/mL and 0. 06 µg/mL | 0.56 | Additivity | |||
| 1.8 µg/mL and 0.06 µg/mL | 0.53 | Additivity | |||
| 0.9 µg/mL and 0.06 µg/mL | 0.5 | Synergism |
* MIC values µg/mL; FICI ≤ 0.5 = synergism; 0.5 < FICI < 1 = additivity; 1 < FICI < 2 = indifference and FICI > 2 = antagonism.