Table 1.
Overlap between the genes categorized under Gene Ontology ID 0008380 and the list of genes that either show increased or decreased expression during replicative senescence of human cells available in the CellAge Database (https://genomics.senescence.info/cells/, accessed on 11 December 2023). The table presents the results of matching the 1159 human orthologs of RNA binding proteins categorized under Gene Ontology ID 0008380 with the genes listed in the CellAge database. The trends of expression (over- or under-expression) associated with aging for these genes, as well as the effects (induction or inhibition) of these changes on the senescent phenotype, are shown.
| Gene Symbol | Expression | Senescence Effect |
|---|---|---|
| AHNAK2 | Over-expressed | |
| RBM24 | Over-expressed | |
| ALYREF | Under-expressed | |
| BUD13 | Under-expressed | |
| C1QBP | Under-expressed | |
| CWF19L1 | Under-expressed | |
| DAZAP1 | Under-expressed | |
| DCPS | Under-expressed | |
| DDX39A | Under-expressed | |
| DHX15 | Under-expressed | |
| EIF4A3 | Under-expressed | |
| FUS | Under-expressed | |
| GEMIN6 | Under-expressed | |
| HNRNPA1 | Under-expressed | Inhibits |
| HNRNPA2B1 | Under-expressed | |
| HNRNPA3 | Under-expressed | Inhibits |
| HNRNPC | Under-expressed | Induces |
| HNRNPF | Under-expressed | |
| HNRNPH1 | Under-expressed | |
| HNRNPH3 | Under-expressed | |
| HNRNPM | Under-expressed | |
| HNRNPU | Under-expressed | |
| KHDRBS1 | Under-expressed | |
| KHSRP | Under-expressed | |
| LSM2 | Under-expressed | |
| LSM3 | Under-expressed | |
| LSM5 | Under-expressed | |
| LSM6 | Under-expressed | |
| NPM1 | Under-expressed | Inhibits |
| PRPF38A | Under-expressed | |
| PRPF4 | Under-expressed | |
| PTBP1 | Under-expressed | |
| RBMX | Under-expressed | |
| RSRC1 | Under-expressed | |
| SF3B3 | Under-expressed | |
| SFPQ | Under-expressed | |
| SNRNP40 | Under-expressed | |
| SNRPA | Under-expressed | |
| SNRPB | Under-expressed | |
| SNRPB2 | Under-expressed | |
| SNRPC | Under-expressed | |
| SNRPD1 | Under-expressed | |
| SNRPE | Under-expressed | |
| SNRPF | Under-expressed | |
| SRSF3 | Under-expressed | |
| SRSF7 | Under-expressed | |
| SYNCRIP | Under-expressed | |
| THOC1 | Under-expressed | |
| TRA2B | Under-expressed | |
| TSEN15 | Under-expressed |