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. 2023 Nov 25;13(12):1707. doi: 10.3390/biom13121707

Figure 3.

Figure 3

Cohort 1, training dataset. (A) Sensitivity, specificity, and accuracy obtained at varying thresholds of ranked-frequency for TCR-α, TCR-β, and both TCR-α and TCR-β in cohort 1, training dataset. (B) Logo plots of the sequences TCR-α (left) and TCR-β (right) sequences of length 11 that are included in the model. Logo plots for sequences of all length are included in the Supplementary Figures S7 and S8. (C) Heatmap showing ranked-frequency for the sequences included in the TCR-α model with a threshold of 0.6 ranked-frequency, and (D) heatmap showing ranked-frequency for the sequences included in the TCR-β model with a threshold of 0.2 ranked-frequency. Red labels indicate patients with CeD on gluten-containing diets, green labels indicate patients with CeD on gluten-free diets, and blue labels indicate controls. Light colours represent absence of the sequence in that individual, whilst dark colours represent the presence of the sequence at high ranked-frequency.