Table 1.
Implant placement in patients receiving head and neck RT.
| PubMedID | First Author | Year | Study Design | No. of Included Studies | No. of Included Patients | Mean Delay RT—Implant Placement | Implant Survival | Other Risk Factors Associated with Reduced Implant Survival | Follow-Up Time | Conclusions/Reccomandations |
|---|---|---|---|---|---|---|---|---|---|---|
| 31612191 | Di Carlo, S. [71] | 2019 | Retrospective study | / | 17 | 14 | 90.50% | / | >12 m | Better outcomes when the implant was placed at least after 14 months and not loaded until at least 6 months after placement. |
| 34903387 | Shokouhi, B. [59] | 2022 | Systematic review and meta-analysis | 7 | 441 | 6–18 m | / | RT doses > 50 Gy Implant placed in the maxilla | 1–14 y | Implant survival is significantly lower in RT compared with non-RT patients (p < 0.001). Implant placement should be delayed by at least six months following RT. |
| 34255187 | Schiegnitz, E. [62] |
2021 | Retrospective study | / | 164 | 43.6 m | 87.3% (5 y), 80.0% (10 y) at time of surgery—92.5% (5 y), 89.5 (10 y) after oncological treatment | Implant placed in augmented and irradiated bone | 37–49 m | A successful and safe rehabilitation of the irradiated oral cancer patient with high implant survival rates is possible for either secondary or primary placed implants. |
| 33278135 | Veld, MI. [80] |
2021 | Systematic review | 10 | / | / | 90.4–100% | / | 12–174 m | Slightly higher survival of immediately placed implants compared with postponed placed implants (p = 0.81). RT vs. non-RT showed a better survival of immediately placed implants not having received RT (p = 0.10). |
| 31898358 | Koudougou, C. [56] |
2020 | Literature review | 4 | 341 | / | 82–96.7% | / | 29–60 m | The outcomes for implant survival rates appear to be positive for irradiated implants. All mandibular implants were selected for this review. |
| 27034761 | Shugaa-Addin, B. [63] |
2016 | Literature review | 18 | 1175 | / | 74.4–97% | Maxillary implants RT doses > 70 Gy | 0.5–10 | Dental implants may be affected by RT, especially when they are placed in the maxilla, in grafted bone, or after radiation; however, they remain a functional option for the rehabilitation of HNC patients. |
| 20701621 | Korfage, A. [57] |
2010 | Prospective study | / | 50 | Time of surgery | 89.40% | / | 5y | Oral cancer patients can benefit from implants placed during ablative surgery, with a high survival rate of the implants, a high percentage of rehabilitated patients, and a high denture satisfaction up to 5 years after treatment. |
| 25926008 | Zen Filho, EV. [68] |
2016 | Systematic review | 8 | 331 | 1–20 m | / | RT doses > 50 Gy | 1–168 m | The placement of implants in the irradiated bone is viable, and head and neck RT should not be considered as an absolute contraindication for dental rehabilitation with implants. |
| 23742098 | Piardi Claudy, M. [70] |
2013 | Systematic review and meta-analysis | 10 | 39 | / | 13.6% (risk of failure) | Placement of dental implants between 6 and 12 months post-RT | 1–170 m | Placing implants in the bone within a period shorter than 12 months after RT may result in a higher risk of failure. |
m = months, ORN = osteoradionecrosis, RT = radiotherapy, y = years.