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. 2023 Dec 17;15(24):5877. doi: 10.3390/cancers15245877

Figure 2.

Figure 2

Strategies to enhance the survival and persistence of adoptively transferred Tregs. The figure depicts different approaches to enhance the in vivo survival and persistence of Tregs after adoptive Treg transfer; these include administration of low-dose IL-2 or its mutants for selective in vivo stimulation of Tregs and not other immune cells (A), administration of other molecules that can also in vivo boost adoptively transferred Tregs such as TNFSR25 agonistic antibody (B), immunoglobulin (C), rapamycin (D), and cytokine-targeted antibodies (E), upregulation of STAT5 for sustained, IL-2-independent Foxp3 expression, and (F) knock-out of the glucocorticoid receptor (GR) to render Tregs resistant to glucocorticoids (G). Created with BioRender.com (accessed on 7 December 2023).