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. 2023 Dec 18;11(12):3342. doi: 10.3390/biomedicines11123342

Figure 2.

Figure 2

LA improves vascular functions in ischemic stroke under acute hyperglycemia. (A) A representative fluorescent microscopic image showing capillaries in the penumbra region of the ipsilateral brain. The tight bar graph shows quantification of CD3-stained vessels for capillary diameter. LA-treated ischemic brain vessels demonstrate a significant increase in diameter compared to untreated brains. Scale bar: 10 µm. (B) Representative images (left) and quantification of CD31-positive vessels (right). LA reduced vessel length in ischemic brains under hyperglycemic and normoglycemic conditions. Scale bar is 100 µm. (C) A significant difference in plasma glucose concentration between the normoglycemic and hyperglycemic groups after 15 min (left) and 45 min (right) of glucose injection. (D) LA preserves body weight loss in treated animals. (E) LA treatment reduces the mortality rate in animals challenged with ischemic stroke under hyperglycemia. Statistical significance was assessed by ordinary one-way ANOVA and Tukey’s multiple comparisons test (A–E). Graphs represent means ± SD; * p < 0.05; ** p < 0.01; **** p < 0.0001.