Table 5. Hospitalization in children and adolescents with COVID-19 (n=45) in a cohort of 1303 pediatric cases of SARS-CoV-2 infection.

Characteristic		Hospitalized patients (n, %)	p-value
Age group (years)
	0–5 (n=273)	20 (7.3)	<0.001*
	6–11 (n=275)	8 (2.9)
	12–19 (n=755)	17 (2.3)
Sex
	Male (n=642)	23 (3.6)	0.802*
	Female (n=661)	22 (3.3)
Coinfection†
	Yes (n=28)	2 (7.1)	0.252‡
	No (n=1275)	43 (3.4)
Comorbidities§
	Yes (n=122)	10 (8.2)	0.007‡
	No (n=1181)	35 (3.0)
Time Period//
	First Wave – 2020 (n=679)	34 (5.0)	0.001*
	Second Wave – 2021 (n=624)	11 (1.8)

^*Chi-square test;

^†Detected coinfections were Streptococcus pyogenes (n=14), Influenza B (n=8), rhinovirus (n=2), respiratory syncytial virus (n=1), human coronavirus [HKU1] (n=1), rhinovirus and adenovirus (n=1), influenza B and human coronavirus [NL63] (n=1);

^‡Fisher’s exact test;

^§Comorbidities were asthma, diabetes, obesity, neurologic disorders, cardiac diseases, genetic syndromes and conditions causing immunosuppression;

^//The first wave of COVID-19 in Brazil took place during the whole year of 2020 and the second wave began in January 2021.