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. 2023 Dec 5;24(24):17141. doi: 10.3390/ijms242417141

Figure 1.

Figure 1

Immune receptors SIGLEC-5 and SIGLEC-14, and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. (a,b) Histograms from one representative example depict the expression of SIGLEC-5/14 (a) or SIGLEC-14 (b) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. (c) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. (d) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. (c,d) GTEx vs. TCGA databases; normalized to GTEX).