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. 2023 Dec 7;24(24):17216. doi: 10.3390/ijms242417216

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Upregulated PIT1 prevents the fusion of SCVs with lysosomes. (a,b) Immunofluorescence assays to show colocalization of S. Typhimurium with Cathepsin D (a) and M6PR (b). Scale bar = 5 μm. The number indicates the percentage of SCVs colocalized with PIT1 relative to total intracellular SCVs. (c,d) The bar graphs show the percentage of S. Typhimurium localized with Cathepsin D (c) and M6PR (d) in control siRNA- or PIT1 siRNA-transfected cells. (e,f) The bar graphs show the percentage of S. Typhimurium localized with Cathepsin D (e) or M6PR (f) in pcDNA3.1- or pcDNA3.1-PIT1-transfected cells. Data indicate means ± SD (n = 3 slides). The significant differences are represented by p-values determined with Student’s t test.