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Representative histology of the spinal cords in EAE mice. G3: Cross-section from MBP immunohistochemistry spinal cord staining. EAE mice received a daily IP injection of PEPITEM (G3) until day 21 post-EAE induction. There is only patchy vacuolization (O) in white matter with no evidence of demyelination (uniformly myelinated white matter). The leptomeninges (*) appear thin with minimal inflammation. Differential spine section from the prior H&E/LFP staining, (n = 3).
