Fig. 4.

Abscesses are sex-linked in B6N and F1 heterozygous mice. Blue points represent animals that developed abscesses. Experimental parameters are included above each plot and bolded text highlights key variable parameters. Abscess frequencies and exact numbers of animals are included above each group. P values are derived from one-tailed Mann–Whitney U tests (mw) and Fisher exact tests (fe). (A) Female B6N mice are more susceptible to abscess formation than male B6N. In contrast, male B6J trend toward slightly increased abscess formation than females. Both BALB/cJ males and females are resistant to abscess formation (n = 10 to 34, across 7 experiments). (B) Abscess susceptibility is inherited only by females from crosses between B6J and BALB/cJ regardless of the sex of the parents (n = 10 to 16, across 5 experiments). (C) Same as B but using B6N mice instead of B6J (n = 20 to 27, across 5 experiments). P < 0.05 was used to determine statistical significance.