Table 2.
Top 10 pathways belonging to “Organismal Systems” in the significant enrichment of 18 classical pathways.
| Pathway | Level 1 | Level 2 | ID | Up/Down Number | DEG Number | Total Number | p-Value |
|---|---|---|---|---|---|---|---|
| Thermogenesis | Organismal Systems | Environmental adaptation | ko04714 | 11/48 | 59 | 232 | 1.92 × 10−5 |
| Axon guidance | Organismal Systems | Development and regeneration | ko04360 | 13/25 | 38 | 156 | 0.00129021 |
| PPAR signaling pathway | Organismal Systems | Endocrine system | ko03320 | 8/15 | 23 | 82 | 0.001617661 |
| Corticosterone synthesis and secretion | Organismal Systems | Endocrine system | ko04927 | 12/6 | 18 | 59 | 0.00180696 |
| Adrenergic signaling in cardiomyocyte | Organismal Systems | Circulatory system | ko04261 | 13/16 | 29 | 126 | 0.010343082 |
| Cholinergic synapse | Organismal Systems | Nervous system | ko04725 | 6/16 | 22 | 96 | 0.02441011 |
| Chemokine signaling pathway | Organismal Systems | Immune system | ko04062 | 18/17 | 35 | 170 | 0.028186015 |
| Platelet activation | Organismal Systems | Immune system | ko04611 | 12/13 | 25 | 115 | 0.031805019 |
| Retrograde endocannabinoid signaling | Organismal Systems | Nervous system | ko04723 | 5/23 | 28 | 134 | 0.038658635 |
| Aldosterone synthesis and secretion | Organismal Systems | Endocrine system | ko04925 | 10/9 | 19 | 84 | 0.039170725 |