Table 1.
Baseline characteristics of geriatric patients with AF at study inclusion.
| Variable | Patients with Rhythm Control | Patients with Frequency Control | p-Value |
|---|---|---|---|
| number | 43 (6%) | 672 (94%) | - |
| age (years) | 79.7 ± 5.8 | 84 ± 5.8 | <0.001 |
| female gender | 28 (65.1%) | 444 (66.1%) | 0.898 |
| height (cm) | 167 ± 9 | 166 ± 9 | 0.581 |
| weight (kg) | 84.8 ± 16.3 | 76.8 ± 25.9 | 0.046 |
| Barthel index | 36 ± 12 | 34 ± 13 | 0.374 |
| MMS | 22 ± 7 | 21 ± 7 | 0.398 |
| CHA2DS2Vasc | 3.86 ± 1.06 | 4.18 ± 1.16 | 0.082 |
| HASBLED | 3.42 ± 0.91 | 3.56 ± 0.90 | 0.334 |
| heart rate (bpm) | 73 ± 19 | 75 ± 15 | 0.527 |
| creatinine (µmol/L) | 126 ± 48 | 105 ± 51 | 0.008 |
| ALAT (µmol/L) | 0.44 ± 0.28 | 0.45 ± 0.70 | 0.904 |
| ASAT (µmol/L) | 0.54 ± 0.36 | 0.54 ± 0.57 | 0.994 |
| bilirubin (µmol/L) | 13 ± 13 | 12 ± 7 | 0.704 |
| hypertension | 34 (79.1%) | 579 (86.2%) | 0.197 |
| diabetes | 5 (11.6%) | 79 (11.8%) | 0.98 |
| heart failure | 32 (74.4%) | 421 (62.6%) | 0.12 |
| previous stroke | 9 (20.9%) | 194 (28.9%) | 0.263 |
| any antiplatelet medication | 7 (16.3%) | 84 (12.5%) | 0.49 |
| aspirin | 4 (9.3%) | 62 (9.2%) | 0.987 |
| clopidogrel | 5 (11.6%) | 34 (5.1%) | 0.066 |
| any OAC | 35 (81.4%) | 553 (82.3%) | 0.881 |
| VKA | 2 (4.7%) | 52 (7.7%) | 0.458 |
| dabigatran | 0 (0%) | 28 (4.2%) | 0.172 |
| rivaroxaban | 5 (11.6%) | 98 (14.6%) | 0.593 |
| apixaban | 18 (41.9%) | 245 (36.5%) | 0.476 |
| edoxaban | 10 (23.3%) | 133 (19.8%) | 0.582 |
| CCB | 10 (23.3%) | 204 (30.4%) | 0.324 |
| beta blockers | 31 (72.1%) | 515 (76.6%) | 0.497 |
| ACE inhibitor | 28 (65.1%) | 402 (59.8%) | 0.492 |
| digitalis glycosides | 4 (9.3%) | 98 (14.6%) | 0.337 |
| amiodarone | 33 (76.7%) | 0 (0%) | <0.001 |
| history of ablation | 10 (23.3%) | 0 (0%) | <0.001 |
| LAAC | 2 (4.7%) | 12 (1.8%) | 0.189 |
Abbreviations: MMS = Mini-Mental Status; bpm = beats per minute; ALAT = alanine aminotransferase; ASAT = aspartate aminotransferase; OAC = oral anticoagulation; VKA: vitamin K antagonist oral anticoagulation; CCB = calcium channel blocker; ACE = angiotensin-converting enzyme; LAAC = left atrial appendage closure.