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. 2023 Dec 18;12(24):7752. doi: 10.3390/jcm12247752

Table 2.

CMR parameter for risk stratification of SCD and their limitations.

Characteristics Limitations
LGE Evidence of myocardial scar extension, pattern and localization as risk predictor for VA/SCD Contraindication of the use of contrast in renal insufficiency
Heterogenicity of the methods for evaluating and quantifying LGE
Limited predictive power for VF/polymorphic VT
T1 mapping/ECV Quantification of myocardial fibrosis, oedema and fat accumulation
Use regardless renal function
Higher native T1 values are associated with arrhythmic events
Measurement variability due to heart rate, magnetic field strength and specific CMR protocol
Data acquisition susceptibility to motion artefact, inadequate breath holding, amount and speed of contrast injection
T1/ECV values influenced by oedema, infiltrative disease and inflammation
Strain imaging Evaluation of regional myocardial dysfunction and deformation Underestimation due to low temporal resolution
Cut-off values variability
Lack reliability of the radial and segmental strain values

LGE: Late gadolinium enhancement. ECV: extracellular volume. VA: ventricular arrhythmias. SCD: sudden cardiac death. VF: ventricular fibrillation. VT: ventricular tachycardia. CMR: cardiac magnetic resonance.