Table 1.

Simple examples of conversion from regulator-reaction equations to mathematical equations

(K_m) Michaelis constant, (V_max) maximum rate constant, (k) rate constant, (g₁, g₂) power coefficients, (ka) association rate constant, (ks) dissociation rate constant, (kx) conversion rate constant, (km) transcription rate constant, (kp) translation rate constant. The square brackets [] indicate the molar concentration and the suffix 0 indicates the total concentration. Actually, since biochemical networks include various complicated reactions, such as transcription regulations with multiple activators and suppressors, formation/degradation of multicomponent molecules, and complex modifications, the detailed rules must be created (Supplemental Method 1).