Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dendritic cells (DC) start the immunological cascade in psoriasis and produce IL-1b, IL-12, and IL-23. The most crucial cytokine pathway is the IL-17/IL-23 axis. IL-17, IL-21, and IL-22 cause epidermal barrier dysfunction and keratinocyte proliferation. IL-17 stimulates many proliferative pathways, such as NOTCH, ERK1, and NF-Kb.
