Table 1.
Demographic and clinicopathological characteristics of the population of the study (n = 849).
| Patient Characteristics | cSCC in Organ Transplant Recipients (n = 64) n (%) or Mean (SD) |
cSCC in Immunocompetent Patients (n = 785) n (%) or Mean (SD) |
p-Value |
|---|---|---|---|
| Sex | |||
| Male Female |
52 (81.2%) 12 (18.8%) |
557 (71.0%) 228 (29.0%) |
NS |
| Age at diagnosis (years) | |||
| 64.50 (12.62) | 79.71 (10.08) | <0.001 | |
| Type of community | |||
| Urban Rural |
22 (34.4%) 42 (65.6%) |
362 (46.1%) 423 (53.9%) |
NS |
| Personal history of skin cancer | |||
| No NMSC Melanoma NMSC + melanoma |
22 (34.4%) 42 (65.6%) 0 (0%) 0 (0%) |
381 (48.5%) 393 (50.1%) 8 (1.0%) 3 (0.4%) |
0.02 |
| Organ transplanted | |||
| Kidney Liver Cardiac Multivisceral |
52 (81.3%) 3 (4.7%) 7 (10.9%) 2 (3.1%) |
||
| Operating group | |||
| Dermatology | 24 (37.5%) | 372 (47.4%) | |
| Plastic surgery | 28 (43.7%) | 304 (38.7%) | |
| Maxillofacial surgery | 9 (14.1%) | 50 (6.4%) | NS |
| Primary care | 1 (1.5%) | 31 (3.9%) | |
| Others | 2 (3.1%) | 28 (3.6%) | |
| Tumor Location | |||
| Head and neck Upper limbs Lower limbs Trunk |
48 (75%) 13 (20.3%) 1 (1.6%) 2 (3.1%) |
659 (84.1%) 67 (5.5%) 38 (4.8%) 20 (2.6%) |
NS |
| Primary SCC Major diameter (cm) | |||
| 1.75 (1.55) | 1.87 (1.52) | NS | |
| Depth of invasion (mm) | |||
| 4.58 (2.72) | 4.64 (3.16) | NS | |
| Clark level | |||
| II III IV V |
2 (3.5%) 19 (33.3%) 23 (40.4%) 13 (22.1%) |
77 (11.9%) 161 (24.9%) 188 (29.1%) 219 (33.9%) |
NS |
| Histologic differentiation |
|||
| Poor Moderate Well |
7 (11.5%) 26 (42.6%) 28 (45.9%) |
100 (13.0%) 336 (43.8%) 332 (43.2%) |
NS |
| Perineural invasion | |||
| Absent Present |
57 (89.1%) 7 (10.9%) |
724 (97.7%) 18 (2.3%) |
NS |
| Lymphovascular invasion | |||
| Absent Present |
63 (98.4%) 1 (1.6%) |
767 (97.7%) 18 (2.3%) |
NS |
| Involvement of deep structures | |||
| Absent Fascia Muscle Cartilage Bone |
56 (87.5%) 4 (6.3%) 1 (1.6%) 1 (1.6%) 2 (3.1%) |
685 (87.3%) 58 (7.4%) 23 (2.9%) 9 (1.1%) 10 (1.3%) |
NS |
| Surgical margins status | |||
| Negative Positive |
48 (75%) 16 (25%) |
612 (77.9%) 173 (22.1%) |
NS |
| Adjuvant radiotherapy | |||
| 4 (6.25%) | 41 (5.2%) | NS | |
| Local recurrence | |||
| Absent Present |
54 (84.4%) 10 (15.6%) |
684 (87.1%) 101 (12.9%) |
NS |
| Metastasis | |||
| Absent Present |
60 (93.8%) 4 (6.3%) |
746 (95.0%) 39 (5%) |
NS |
| Metastasis site | |||
| Lymph nodes Distant |
2 (3.1%) 2 (3.1%) |
38 (4.8%) 1 (0.1%) |
NS |
cSCC: cutaneous squamous cell carcinoma; NMSC: non-melanoma skin cancer; NS: non-significant (p > 0.05); SD: standard deviation.