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Calcium-handling in excitation–contraction (EC) coupling. Schematic overview of key Ca2+-handling proteins and their roles in the process of EC coupling. NCX, Na+/Ca2+ exchanger; PM, Plasma membrane; RyR, Ryanodine receptor; SERCA2a, Sarco/endoplasmic reticulum ATPase type-2a; SR, Sarcoplasmic reticulum; TT, Transverse tubule.
