Table 3.
Genotypes and allele frequencies of Calpain-10 gene SNP-19 (rs3842570) in controls and diabetic patients.
Genotypes | Controls (No. 128) |
Diabetic Patients (No. 129) |
OR (95%CI) |
p-Value | Controls (No. 128) |
Diabetic Nephropathy (No. 80) |
OR (95%CI) |
p-Value |
---|---|---|---|---|---|---|---|---|
n (%) | n (%) | n (%) | n (%) | |||||
11 | 71 (55.5) | 50 (38.8) | Reference | Reference | 71 (55.5) | 27 (33.75) | Reference | Reference |
12 | 51 (38.9) | 57 (44.2) | 1.58 (0.9–2.6) |
0.08 | 51 (38.9) | 35 (43.75) | 1.8 (0.9–3.3) | 0.06 |
22 | 6 (4.7) | 22 (17.1) | 5.2 (1.9–13.7) |
0.0009 | 6 (4.7) | 18 (22.5) | 7.8 (2.8–21.9) | 0.0001 |
Dominant
model |
||||||||
11 + 12 | 122 | 107 | 4.8 (1.6–10.7) |
0.0028 | 122 | 62 | 5.8 (2.1–15.3) |
0.0004 |
22 | 6 | 22 | 6 | 18 | ||||
Recessive
model |
||||||||
11 | 71 | 50 | 2.4 (1.3–4.4) |
0.0021 | 71 | 27 | 3.2 (1.7–5.9) |
0.0002 |
12 + 22 | 56 | 79 | 56 | 53 | ||||
Allele | ||||||||
1 | 193 | 157 | 1.97 (2.8–13.4) |
0.0004 | 193 | 89 | 2.4 (1.6–3.7) |
<0.0001 |
2 | 63 | 101 | 63 | 71 |