Table 5.
Association of Calpain-10 SNP-19 (rs3842570) genotypes with biochemical markers in T2DM patients (n = 129).
| Genotypes | Calpain-10 SNP 19 Genotypes | p-Value | P1 | P2 | P3 | |||
|---|---|---|---|---|---|---|---|---|
| Variables | 11 (No. 51) |
12 (No. 56) |
22 (No. 22) |
|||||
| Glucose (mg/dL) | 246.1 ± 82.6 | 245.7 ± 48.1 | 282.5 ± 59.4 | 0.063 | 0.97 | 0.03 | 0.02 | |
| HbA1c (%) | 6.8 ± 0.5 | 7.1 ± 0.6 | 7.3 ± 0.6 | 0.012 | 0.027 | 0.006 | 0.25 | |
| Urea (mmol/L) | 11.18.1 ± 1.4 | 15.6 ± 1.8 | 14.2 ± 1.2 | 0.12 | 0.041 | 0.29 | 0.61 | |
| Creatinine (μmol/L) |
161.5 ± 22.3 | 289 ± 39.1 | 172 ± 20.7 | 0.005 | 0.002 | 0.84 | 0.028 | |
| eGFR (mL/min/1.73 m2) | 86.4 ± 10.5 | 84.2 ± 11.2 | 82.01 ± 7.9 | 0.27 | 0.31 | 0.12 | 0.42 | |
| Albuminuria | 75.1 ± 9.56 | 84.1 ± 9.04 | 87.9 ± 13.8 | 0.69 | 0.49 | 0.46 | 0.84 | |
| Serum TGF-β (ng/mL) |
6.7 ± 2.8 | 6.3 ± 2.4 | 6.4 ± 2.04 | 0.73 | 0.47 | 0.57 | 0.97 | |
| Serum IL-17 (pg/mL) |
121.7 ± 73.5 | 105.7 ± 59.6 | 92.5 ± 41.8 | 0.16 | 0.19 | 0.07 | 0.41 | |
| Serum Zn (µg/dL) |
68.6 ± 13.8 | 67.7 ± 15.7 | 75.3 ± 18.4 | 0.13 | 0.71 | 0.09 | 0.05 | |
| Serum Cu (µg/dL) |
222.5 ± 42.6 | 231.4 ± 43.7 | 204.7 ± 27.9 | 0.042 | 0.3 | 0.09 | 0.01 | |
| Serum Mg (µg/dL) |
1.70 ± 0.23 | 1.75 ± 0.24 | 1.72 ± 0.26 | 0.47 | 0.22 | 0.53 | 0.75 | |
| Cu/Zn ratio |
3.3 ± 0.9 | 3.6 ± 1.16 | 2.9 ± 1.16 | 0.054 | 0.26 | 0.12 | 0.031 | |
| mRNA-375 fold change | 4.1 ± 2.63 | 4.05 ± 1.8 | 3.3 ± 2.6 | 0.42 | 0.85 | 0.20 | 0.24 | |
The data are expressed as means ± SD. The one-way analysis of variance (ANOVA) test followed by the post hoc test was utilised for comparison of means of groups. P1: significance of genotype 11 against 12. P2: significance of genotype 11 against genotype 22. P3: significance between genotypes 12 and 22.