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Ten selected somatic mutations detected in Sample2. Genes with low somatic allele frequency (<0.5) are not reliable to detect ctDNA (gray). The reliable genes APC, TP53, FLNB, PI4KA, and PIK3CA are high in preoperation (PT) and relapse (Metastasis), but a relative decrease happens after the first operations (post OP1), and ctDNA disappears after the second operation (post OP2). This is consistent with the clinical observations in the case study (see Section 3.4 below).
