Table 4.
Postoperative multivariate Cox regression analyses for prediction of RFS, CSS, and OS.
| Characteristic | Recurrence-Free Survival | Cancer-Specific Survival | Overall Survival | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | p-Value | HR | 95%CI | p-Value | HR | 95%CI | p-Value | |
| SII (Reference: low) | |||||||||
| High | 2.20 | 1.28, 3.78 | 0.004 | 1.65 | 0.89, 3.08 | 0.111 | 1.79 | 1.13, 2.84 | 0.012 |
| Age | 0.97 | 0.51, 1.83 | 0.926 | 1.52 | 0.64, 3.64 | 0.338 | 1.25 | 0.68, 2.72 | 0.462 |
| Smoke (Reference: no) | |||||||||
| Smoke | 1.22 | 0.71, 2.12 | 0.462 | 2.06 | 0.99, 4.29 | 0.052 | 1.68 | 0.99, 2.26 | 0.050 |
| Gender (Reference: male) | |||||||||
| Female | 1.47 | 0.80, 2.70 | 0.213 | 1.80 | 0.93, 3.48 | 0.076 | 1.35 | 0.80, 2.26 | 0.252 |
| Pathological tumor stage | |||||||||
| (Reference: pT0/pTa/pTispT1) | |||||||||
| pT2 | 1.58 | 0.62, 4.01 | 0.331 | 1.00 | 0.32, 3.15 | 0.992 | 1.50 | 0.68, 3.29 | 0.304 |
| pT3/pT4 | 2.92 | 1.18, 7.23 | 0.020 | 3.03 | 1.21, 7.59 | 0.017 | 3.33 | 1.63, 6.78 | 0.001 |
| Lymphovascular invasion | 1.02 | 0.41, 2.48 | 0.05 | 0.94 | 1.75, 8.86 | 0.903 | 0.92 | 0.46, 1.82 | 0.828 |
| Lymph node invasion | 3.63 | 2.02, 6.50 | <0.001 | 3.94 | 1.75, 8.86 | 0.001 | 2.91 | 1.63, 5.19 | <0.001 |
| Adjuvant chemotherapy | 1.50 | 0.85, 2.63 | 0.157 | 0.48 | 0.21, 1.10 | 0.086 | 0.67 | 0.38, 1.19 | 0.176 |
| C-index | |||||||||
| Model with SII | 0.79 | 0.76 | 0.74 | ||||||
| Model without SII | 0.77 (+2%) | 0.76 | 0.73 (1%) | ||||||
| (p = difference model) | 0.002 | 0.08 | 0.01 | ||||||
HR = Hazard ratio; CI = Confidence interval; SII = Systemic immune-inflammation index; Bold: the statistical correlation between the calculations.