Table 1.
Review of clinical studies investigating the use of stem cells and their extracellular vesicles for the treatment of POI according to clinicaltrials.gov.
| Stem Cell Therapy | Name of the Clinical Study | Link to Clinical Study | Status | Country |
|---|---|---|---|---|
| Autologous bone marrow transplant | Autologous bone marrow transplantation for POI | NCT02779374 | Unknown | Egypt |
| Autologous mesenchymal bone marrow stem cells | Autologous bone marrow stem cell transplantation in patients with POI | NCT03069209 | Active | Jordan |
| Intraovarian injection of adipose-derived stromal cells | Transplantation of autologous adipose-derived stem cells in patients with POI | NCT02603744 | Unknown | Iran |
| Stem cells derived from bone marrow | Restoring the reserve in patients with POI with stem cells | NCT02696889 | Active | USA |
| Mesenchymal stem cells derived from the umbilical cord | Transplantation of mesenchymal stem cells derived from the umbilical cord, with the introduction of collagen in patients with POI | NCT02644447 | Completed | China |
| Autologous mesenchymal bone marrow stem cells | Autologous mesenchymal stem cell transplantation in women with POI | NCT02062931 | Unknown | Egypt |
| Transplantation of autologous bone marrow stem cells | Autologous stem cell ovarian transplantation | NCT02240342 | Unknown | Spain |
| Autologous Very Small Embryonic-Like Stem Cells | Very Small Embryonic-Like Stem Cells for ovary | NCT03985462 | Withdrawn | China |
| Transplantation of Human Umbilical Cord Blood Mononuclear Cells and human umbilical cord mesenchymal stem cells with hormone replacement therapy | Stem-cell-therapy-combined hormone replacement therapy in patients with premature ovarian failure | NCT01742533 | Unknown | China |
| Stem cell therapy | Stem cell therapy and growth factor ovarian in vitro activation (SEGOVA) | NCT04009473 | Unknown | MaltaSerbiaNorth Macedonia |
| Transplantation of UCA-PSC plus hormone replacement treatment (HRT) (UCA-PSC group)/transplantation of WJ-MSC plus HRT (collagen/WJ-MSC group) | Effects of UCA-PSCs in women with POF | NCT05138367 | Completed | China |
| Autologous bone marrow stem cell | Rejuvenation of premature ovarian failure with stem cells (ROSE-1) | NCT02696889 | Completed | United States |
| Transplantation of adipose-derived stromal cells | Effects of ADSC therapy in women with POF | NCT01853501 | Unknown | China |
| Stem cell therapy | Ovarian stem cells from women with ovarian insufficiency | NCT01702935 | Completed | United States |