FIG. 4.

Alignment of bacterial predicted protein sequences showing conservation of GGDEF and EAL domains. Residues with identity or conservative substitution in 100 and ≥80% of the sequences are shaded in black and gray, respectively. Identities displayed between each sequence and the A. xylinum (Ax) PDEA1 and DGC1 sequences, respectively, are shown in parentheses below. The amino acid sequences shown are from E. coli (Ec) YCIR, GenBank accession no. D90766 (50 and 28%); Bacillus subtilis (Bs) ykoW, GenBank Z99110 (50 and 26%); Synechocystis strain PCC6803 (Sy) slr0359, GenBank D63999 (49 and 30%); Rhizobium sp. strain NGR234 (Rh) Y4LL, GenBank AE000083 (48 and 32%); Mycobacterium tuberculosis (Mt) Y07I, GenBank Z75555 (31 and 32%).