Table 2.
Total (birth + fetal) prevalence of neural-tube defects (NTDs) in informative offspring of women taking folic acid-containing multivitamin supplement and no (multivitamin or folic acid) supplement during periconceptional period in the two Hungarian intervention trials.
| Intervention trials | Supplement | No supplement |
|---|---|---|
| Randomized controlled trial (RCT) | ||
| Number of offspring | 2,471 | 2,391 |
| Expected/observed number of NTD | 6.9/0 | 6.7/6* |
| RR (with 95% CI) | 0.07 (0.04-0.13) | |
| Two-cohort controlled trial (TCT) | ||
| Number of offspring | 3,056 | 3,056 |
| Expected/observed number of NTDs | 8.5/1** | 8.5/9*** |
| OR (with 95% CI) | 0.11 (0.01-0.91) | |
| Pooled data | ||
| Number of offspring | 5,527 | 5,447 |
| Expected/observed number of NTDs | 15.4/1 | 15.2/15 |
| OR (with 95% CI) | 0.08 (0.01-0.47) | |
* Anencephaly 2, Anencephaly +spina bifida (lumbal, thoracolumbal) 2, Spina bifida 2, thoracolumbal 1, lumbosacral 1
** Anencephaly 1
***Anencephaly 1, Spina bifida 8, thoracolumbal 1, lumbal 4, lumbal 4, lumbosacral 3