Table 5.
The dataset of the HCCSCA, 1980-1996 regarding high dose of folic acid supplementation in the first and second month of gestation.
| Grand total | First month | POR 95% CI | Second month | POR 95% CI | |||||
|---|---|---|---|---|---|---|---|---|---|
| No. | No. | % | No. | % | |||||
| Total controls | 38,151 | 1,526 | 4.0 | referent | 2,617 | 6.9 | referent | ||
| Neural-tube defects | 1,202 | 32 | 2.7 | 0.68 | 0.47 – 0.97 | 66 | 5.5 | 0.80 | 0.62 – 1.03 |
| Candidate CAs | |||||||||
| Cleft lip ± palate | 1,374 | 48 | 3.5 | 0.89 | 0.67 – 1.20 | 76 | 5.5 | 0.82 | 0.64 – 1.03 |
| Posterior cleft palate | 601 | 12 | 2.0 | 0.50 | 0.28 – 0.89 | 29 | 4.8 | 0.70 | 0.48 – 1.02 |
| Cardiovascular CAs | 4,479 | 142 | 3.2 | 0.81 | 0.68 – 0.96 | 227 | 5.1 | 0.75 | 0.65 – 0.86 |
| Rectal/anal atresia/stenosis | 220 | 4 | 1.8 | 0.46 | 0.17 – 1.23 | 6 | 2.7 | 0.39 | 0.17 – 0.88 |
| Obstructive urinary CAs | 502 | 13 | 2.6 | 0.64 | 0.37 – 1.12 | 24 | 4.8 | 0.70 | 0.46 – 1.06 |
| Limb reduction CAs | 548 | 15 | 2.7 | 0.69 | 0.41 – 1.16 | 33 | 6.0 | 0.89 | 0.62 – 1.26 |
| Congenital pyloric stenosis | 241 | 11 | 4.6 | 1.16 | 0.63 – 2.13 | 11 | 4.6 | 0.65 | 0.35 – 1.19 |
| Omphalocele | 238 | 10 | 4.2 | 1.07 | 0.57 – 2.02 | 10 | 4.2 | 0.60 | 0.32 – 1.13 |
| New candidate CAs | |||||||||
| Hypospadias | 3,038 | 83 | 2.7 | 0.68 | 0.55 – 0.86 | 163 | 5.4 | 0.78 | 0.66 – 0.92 |
| Poly/syndactyly | 1,744 | 43 | 2.5 | 0.62 | 0.45 – 0.84 | 104 | 6.0 | 0.88 | 0.72 – 1.08 |
| Multiple CAs | 1,349 | 34 | 2.5 | 0.64 | 0.45 – 0.90 | 69 | 5.1 | 0.75 | 0.59 – 0.96 |
| Others | 7,307 | 237 | 3.2 | 0.80 | 0.70 – 0.92 | 403 | 5.5 | 0.79 | 0.71 – 0.88 |
| Total | 22,843 | 684 | 3.0 | 0.76 | 0.70 – 0.84 | 1,221 | 5.3 | 0.79 | 0.73 – 0.84 |