Table 4.
gyrA gene amino acid substitutions associated with quinolone (LVF, MOXI, and CIP)-resistant H. pylori strains.
| No. | Strain Name |
MIC (µg/mL) | gyrA Mutation | |||||
|---|---|---|---|---|---|---|---|---|
| LVF | MOXI | CIP | N87 | A88 | D91 | |||
| 1 | Uvs | 103 | 32 | 8≤ | 16≤ | I | ||
| 2 | Uvs | 61 | 16 | 8≤ | 16≤ | I | ||
| 3 | UB | 97 | 8 | 8≤ | 16≤ | I | ||
| 4 | UB | 129 | 8 | 8≤ | 16≤ | K | ||
| 5 | UB | 168 | 8 | 8≤ | 16≤ | K | ||
| 6 | UB | 189 | 8 | 8≤ | 16≤ | K | ||
| 7 | Uvs | 131 | 8 | 8≤ | 16≤ | K | ||
| 8 | Uvs | 136 | 8 | 8≤ | 16≤ | K | ||
| 9 | Kh | 160 | 8 | 8≤ | 16≤ | K | ||
| 10 | Go | 150 | 8 | 8≤ | 16≤ | K | ||
| 11 | Ke | 3 | 8 | 8≤ | 16≤ | K | ||
| 12 | Ke | 47 | 8 | 8≤ | 16≤ | K | ||
| 13 | Ke | 59 | 8 | 8≤ | 16≤ | K | ||
| 14 | Ke | 160 | 4 | 8≤ | 16≤ | K | ||
| 15 | Ke | 2 | 2 | 4 | 16≤ | K | ||
| 16 | UB | 221 | 8 | 8≤ | 16≤ | P | ||
| 17 | UB | 178 | 8 | 8≤ | 16≤ | N | ||
| 18 | UB | 198 | 8 | 8≤ | 16≤ | N | ||
| 19 | Go | 129 | 8 | 8≤ | 16≤ | N | ||
| 20 | Uvs | 97 | 4 | 8≤ | 16≤ | N | ||
| 21 | UB | 29 | 8 | 8≤ | 16≤ | G | ||
| 22 | UB | 217 | 4 | 8≤ | 8 | G | ||
| 23 | Kh | 93 | 2 | 8≤ | 16≤ | G | ||
| 24 | UB | 219 | 8 | 8≤ | 16≤ | Y | ||
| 25 | Go | 1 | 4 | 8≤ | 16≤ | Y | ||
| 26 | Ke | 1 | 4 | 8≤ | 8 | Y | ||
| 27 | Uvs | 23 | 4 | 4 | 8 | Y | ||
| 28 | Kh | 111 | 4 | 8≤ | 16≤ | Y | ||
| 29 | Ke | 87 | 16 | 1 | 16≤ | K | ||
| 30 | Ke | 119 | 8 | 1 | 16≤ | K | ||
| 31 | Ke | 4 | 0.5 | 8≤ | 16≤ | G | ||
| 32 | Ke | 133 | 8 | 8≤ | 4 | |||
| 33 | Uvs | 113 | 4 | 8≤ | 16≤ | |||
| 34 | Kh | 95 | 4 | 8≤ | 16≤ | |||
| 35 | Kh | 173 | 2 | 4 | 8 | |||
| 36 | UB | 30 | 8 | 0.5 | 0.5 | |||
| 37 | Ke | 86 | 4 | 8≤ | 0.5 | |||
| 38 | Go | 168 | 2 | 0.5 | ≤0.25 | |||
| 39 | UB | 72 | 0.5 | 8≤ | 16≤ | |||
| Strains sensitive to quinolones (n = 38) | N | A | D | |||||
N, asparagine; A, alanine; Y, tyrosine; D, aspartic acid; K, lysine; P, proline; G, glycine. Orange indicates resistance to all three quinolones and green indicates resistance to one or two quinolones; blue indicates the corresponding mutations. UB, Ulaanbaatar capital city; Go, Umnugovi; Ke, Khentii; Kh, Khuvsgul; MIC, minimal inhibitory concentration; LVF, levofloxacin; MOXI, moxifloxacin; CIP, ciprofloxacin.