Table 2.

HIV-1 integrase inhibitory effect and cytotoxicity of compound 3 derivatives.

Compd.	IC50 (μM)	CC50 (μM) a	Compd.	IC50 (μM)	CC50 (μM)
15	2.34 ± 0.31	>80	19a	1.05 ± 0.32	37.58 ± 3.64
16a	3.47 ± 0.82	>80	19b	1.70 ± 0.15	29.37 ± 1.76
16b	1.06 ± 0.25	>80	20a	0.13 ± 0.02	>80
17a	0.93 ± 0.07	>80	20b	0.64 ± 0.06	>80
17b	0.39 ± 0.09	>80	21	6.85 ± 0.66	>80
18	1.92 ± 0.07	45.29 ± 2.73	RAL	0.06 ± 0.04	>80

^a Concentration that inhibits the proliferation of MT-4 cells by 50%. All data values are the average of at least three independent experiments.