Table 1.

XBP1s regulate various genes involved in lipid synthesis and lipid storage by promoting the expression of lipogenic genes. The table displays some of the key lipogenic genes promoted by XBP1s.

Modulators	Full Name	Roles in Lipogenesis
FAS	Fatty acid synthase	XBP1s promotes the expression of the FAS gene, contributing to fatty acid synthesis. FAS is an enzyme responsible for generating fatty acids and plays a crucial role in lipid metabolism.
SREBP1c	Sterol regulatory element-binding protein 1c	XBP1s regulates the expression of the SREBP1c gene, facilitating lipid synthesis. SREBP1c also activates other important genes related to lipid metabolism.
ACC	Acetyl-CoA carboxylase	XBP1s enhances the expression of the ACC gene, increasing the conversion of acetyl-CoA into fatty acids. This process is essential in fatty acid synthesis and is one of the key steps.
DGAT	Diacylglycerol O-Acyltransferase	XBP1s regulates the expression of the DGAT gene, promoting processes related to lipid droplets. This is associated with lipid storage
ChREBP	Carbohydrate-responsive element-binding protein	XBP1s controls the expression of the ChREBP gene, regulating the interaction between carbohydrate metabolism and fatty acid synthesis.
PLIN	Perilipin	XBP1s controls the expression of the PLIN gene, facilitating the perilipin protein found on the surface of lipid droplets. Perilipin stabilizes lipid droplets and regulates lipid storage and movement processes.
CIDE	Cell death-inducing DFFA-like effector	XBP1s contributes to the dynamics of lipid droplets by regulating the expression of certain genes within the CIDE gene family. These genes play a role in modulating the structure and function of lipid droplets.
ATGL	Adipose triglyceride lipase	XBP1s regulates the expression of the ATGL gene, controlling the breakdown of triglycerides in neutral fat. This process is associated with the movement of lipids within lipid droplets.
HSL	Hormone-sensitive lipase	XBP1s further regulates the breakdown of triglycerides in neutral fat by controlling the expression of the HSL gene. This process is related to energy metabolism.