Skip to main content
. 2023 Dec 14;28(24):8095. doi: 10.3390/molecules28248095

Table 4.

Antiproliferative effects of selected nitrovinylanthracenes 19a, 19g and 19i in MCF-7 and MDA-MB-231 human breast cancer cell lines.

graphic file with name molecules-28-08095-i003.jpg
Compound MCF-7
IC50 (μM) a 		MDA-MB-231
IC50 (μM) a
19a 1.85 3.82
19g 5.31 3.78
19i 2.11 3.26
Tamoxifen b 4.12 20

a IC50 values are half-maximal inhibitory concentrations required to block the growth stimulation of MCF-7 and MDA-MB-231 human breast cancer cells. Treatment at eight different concentrations (0.001–50 μM) was used for the determination of the IC50 values for each compound. Values represent the mean ± SEM (error values × 10−6) for three independent experiments performed in triplicate. b The IC50 values for tamoxifen were in good agreement with the reported IC50 values in MCF-7 cells [81] and MDA-MB-231cells [82,83].