Table 5.
Pro-apoptotic effects of nitrostyrene compounds 11g, 11h, 11i, 11j, 11k and 11l in MUTU-I and DG-75 BL cell lines a.
| Compound | Concentration | MUTU-I | DG-75 |
|---|---|---|---|
| (µM) | Apoptosis (%) | Apoptosis (%) | |
| 11g | 10 | 80.9 | 70.6 |
| 11h | 10 | 82.6 | 92.0 |
| 11i | 10 | 84.5 | 86.4 |
| 11j | 10 | 88.3 | 72.3 |
| 11k | 10 | 91.5 | 90.7 |
| 11l | 10 | 91.3 | 85.0 |
| Taxol | 10 | 87.3 | 72.8 |
| Taxol | 1 | 62.8 | 20.7 |
| Vehicle | Ethanol | 13.7 | 1.05 |
a MUTU-I and DG-75 BL cells were treated with compounds 11g, 11h, 11i, 11j, 11k and 11l (10 µM), taxol (10 µM and 1 µM) and control vehicle (1% EtOH (v/v)) for 24 h (MUTU-I) and 48 h (DG-75). The percentage of apoptotic cells was determined by staining with Annexin V-FITC and PI. The experiment was performed as individual replicates on three independent days.