TABLE 1.
Genes contributing to GI colonization in all three strains of K. pneumoniaea
| Gene | Annotation | Log2 (fold change) | ||
|---|---|---|---|---|
| CRE-166 | KPN46 | Z4160 | ||
| aceE | Pyruvate dehydrogenase E1 component | 4.412 | 5.504 | 5.440 |
| acrA | Multidrug efflux pump subunit | 5.906 | 6.935 | 5.512 |
| adhE | Aldehyde-alcohol dehydrogenase | 3.353 | 4.848 | 7.339 |
| arcB | Aerobic respiration control sensor protein | 5.342 | 3.821 | 6.018 |
| bglY | Beta-galactosidase | 6.948 | 2.896 | 5.749 |
| cvpA | Colicin V production protein | 4.611 | 4.449 | 6.031 |
| cydA | Cytochrome bd-I ubiquinol oxidase subunit 1 | 4.387 | 6.933 | 4.731 |
| fnr | Fumarate and nitrate reduction regulatory protein | 4.248 | 6.542 | 5.723 |
| focA | Formate transporter | 6.486 | 7.092 | 6.679 |
| glnA | Glutamine synthetase | 3.667 | 3.755 | 4.313 |
| miaA | tRNA dimethylallyltransferase | 5.773 | 3.856 | 3.992 |
| mtlD | Mannitol-1-phosphate 5-dehydrogenase | 5.711 | 6.709 | 5.990 |
| ompC | Outer membrane porin C | 5.738 | 3.129 | 3.472 |
| pal | Peptidoglycan-associated lipoprotein | 4.172 | 6.183 | 4.662 |
| pflA | Pyruvate formate-lyase 1-activating enzyme | 5.617 | 7.979 | 6.821 |
| pflB | Formate acetyltransferase 1 | 4.766 | 5.270 | 4.077 |
| pgi | Glucose-6-phosphate isomerase | 5.404 | 5.665 | 4.507 |
| ptsI | Phosphoenolpyruvate-protein phosphotransferase | 3.088 | 6.240 | 7.061 |
| purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 3.470 | 4.634 | 4.273 |
| purH | Bifunctional purine biosynthesis protein | 3.710 | 5.209 | 8.324 |
| pykF | Pyruvate kinase I | 4.431 | 4.701 | 3.025 |
| setA | Sugar efflux transporter A | 6.943 | 5.168 | 5.053 |
| tatA | Sec-independent protein translocase protein | 3.384 | 6.061 | 4.829 |
| tatC | Sec-independent protein translocase protein | 3.452 | 5.452 | 5.276 |
| tolA | Tol-Pal system protein | 5.977 | 5.965 | 4.284 |
| yeiE | HTH-type transcriptional activator | 5.445 | 4.572 | 4.522 |
| − | Hypothetical polysaccharide deacetylase | 5.327 | 4.906 | 3.985 |
| carA | Carbamoyl phosphate synthase small subunit | − | 3.917 | 5.662 |
| carB | Carbamoyl phosphate synthase large subunit | 5.267 | − | 4.220 |
a
For each strain, genes with log2 fold change less than −2 and FDR <0.05 were compared. For the carAB two-gene operon, carB met these criteria for CRE-166, whereas carA met these criteria for KPN46 and Z4160.