FIG 4.

Transcriptomic analysis of C. albicans after exposure to HOCl, H₂O₂, or benzoquinone. (A) C. albicans WT cells were treated for 15 min with 5 µM HOCl, 5 µM H₂O₂, and 5 µM benzoquinone, respectively. The Venn diagram displays the number of upregulated genes (log₂ fold change > 1, adjusted P value < 0.1). (B) Principal component analysis of the transcriptome. HOCl treatment samples (1 µM HOCl and 5 µM HOCl) clustered with the non-treatment control (0 µM HOCl). However, H₂O₂ and benzoquinone samples showed variable transcriptome patterns. Dots of the same color represent biological replicates. (C) Gene ontology (GO) term analysis of the upregulated genes under the indicated oxidative stress conditions. Core group genes were upregulated across all treatments, including HOCl, H₂O₂, and benzoquinone. Colors indicate statistical significance, and dot size represents the number of genes in the GO term.