Fig 3.

Antibody constructs that target the top, cryptic side, and outer area of RBD can be grouped similarly among HexaPro binning communities, RBD binning communities, and the conventional classification system. (a-d) Illustration of the four main epitope footprints on RBD surface based on HexaPro epitope binning results. In the top row, RBM is colored in dark pink, RBD mutated residues in B.1.351 variant are colored in gold, and RBD mutated residues in BA.1 but not in B.1.351 are colored in cyan. In the bottom row, footprint illustrations of the main corresponding RBD communities and the corresponding conventional classifications are indicated for each footprint. RBD surface and footprint illustrations were generated from CoVIC-DB (https://CoVICdb.lji.org/) using PDB 7DDD (57).