Fig 5.
CoVIC constructs that show enhanced affinities for B.1.351 HexaPro are more likely to retain neutralization activity against the B.1.351 variant. (a) Ratios of KD values (D614G HexaPro KD / B.1.351 HexaPro KD) are shown. (b) Ratios of IC50 values (D614G HexaPro IC50 / B.1.351 HexaPro IC50) for authentic neutralization assays are shown. IC50 ratios were calculated based on values deposited in the CoVIC database contributed by the University of North Carolina (CoVIC-DB (60); see https://CoVICdb.lji.org/ for detailed values and descriptions of the method). (c) The correlation is shown between the ratio of KD values and the ratio of IC50 values for the constructs in panels a and b. In all panels, each CoVIC construct is colored based on its HexaPro community designation.