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. 2023 Nov 28;9(12):e22843. doi: 10.1016/j.heliyon.2023.e22843

Table 3.

Extraction recovery and matrix effect of withanoside IV, withanolide A and withaferin A.

Analytes Nominal concentration (ng/mL) R1
R2
R3
Recovery (%)
Matrix effect (%)
Mean ± SD (n = 3) Mean ± SD (n = 3) Mean ± SD (n = 3) Mean ± SD (n = 3) Mean ± SD (n = 3)
Withanoside IV LQC (3) 14.67 ± 0.58 15.67 ± 0.58 16.67 ± 0.58 93.61 ± 0.24 94.00 ± 0.21
MQC (30) 170.00 ± 5.29 182.00 ± 3.00 200.00 ± 2.00 93.39 ± 1.52 91.00 ± 1.31
HQC (75) 473.33 ± 5.03 508.67 ± 6.11 544.00 ± 7.21 93.06 ± 0.77 93.51 ± 1.14
Withanolide A LQC (3) 97.00 ± 1.00 106.33 ± 1.53 117.00 ± 1.00 91.23 ± 0.42 90.88 ± 0.56
MQC (30) 1308.33 ± 9.29 1433.67 ± 9.29 1534.67 ± 5.51 91.26 ± 1.02 93.42 ± 0.37
HQC (75) 3371.33 ± 8.14 3680.00 ± 8.54 3993.33 ± 8.33 91.61 ± 0.27 92.15 ± 0.17
Withaferin A LQC (1.5) 275.33 ± 5.51 294.33 ± 4.04 313.00 ± 4.36 93.54 ± 0.66 94.04 ± 0.71
MQC (15) 1825.00 ± 2.00 1989.67 ± 7.37 2191.33 ± 5.86 91.72 ± 0.27 90.80 ± 0.55
HQC (37.5) 4382.67 ± 5.86 4777.33 ± 8.62 5229.33 ± 6.81 91.74 ± 0.05 91.36 ± 0.13

R1 represents analytes spiked before extraction.

R2 represents analytes spiked after extraction.

R3 represents analytes prepared in injection solvent.

Recovery (%) was calculated as R1/R2 × 100.

Matrix effect (%) was calculated as R2/R3 × 100.