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. 2023 Dec 22;44(1):30. doi: 10.1007/s10875-023-01603-7

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Fig. 2 — Identification of putative constitutively active IL6ST gain-of-function variants in liver vs non-liver cancers. A, B Frequency of IL6ST mutation due to in-frame deletions or non-synonymous substitutions in HCA. Meta-analysis is based on four HCA cohorts and COSMIC database. C Frequency of IL6ST mutation due to non-synonymous substitutions in colon and lung cancer. Meta-analysis is based on COSMIC, TCGA, and ICGC databases. D Deletion length showing majority of the variants cluster in the region of p.T183 to p.E195 in D2. D, Domain. Color-coded heat map corresponds to the number of mutated samples at the specified deleted site