Fig. 3.

Analysis of IL6ST eQTL and common variants. A IL6ST eQTL, common variants, and isoforms act to alter gene expression. B Main: Heatmap showing correlation between variants in the IL6ST locus with correlations measured by r² (red) and D′ (blue) demonstrating linkage disequilibrium—where the associations between variants are non-random. Left: known cell/tissue type expression and disease association (data derived from the ClinVar, Decipher, OMIM, and ClinGen disease databases). Below: Map showing position of variants aligned to transcripts of IL31RA, IL6ST, and ANKRD55