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. 2023 Sep 5;28(6):849–859. doi: 10.1007/s12192-023-01376-3

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© The Author(s), under exclusive licence to Cell Stress Society International 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — Effects of NAC administration on histopathological changes in ADR-induced liver tissue. Control (a) and NAC group (b) liver tissues had normal histological appearance. In the ADR group (c); sinusoidal dilatation (triangle), hemorrhagic areas (notched arrow), hepatocyte vacuolızation (thin arrow), foci of inflammation (thick arrow) and hemorrhagic areas (notched arrow) were observed. Histopathological changes were significantly reduced in the ADR + NAC group (d) compared to the ADR group (p < 0.05). Hematoxylin Eosin, scale bar: 200µm, × 100. ADR: Adriamycin; NAC: N-Acetylcysteine