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. 2023 Dec 22;9:467. doi: 10.1038/s41420-023-01755-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Metabolic analysis of iCDM-17, iCDM-34, and CDM-3008 in human, rat, and mouse liver microsomal fractions. B Metabolic analysis of iCDM-34 in vivo. iCDM-34 was injected into human hepatocyte-chimeric mouse, and then iCDM-34 concentration in the blood was measured at 5, 30, 60, 240, 480 min after the injection (n = 1). C iCDM-34 (1 mg/kg, i.v.) was injected with or without ETV (0.03 mg/kg, p.o.) once a day. After 21 days of injections, DNA was purified from the liver, and then HBV DNA (D, E) levels with or without ETV were measured by qPCR. The data are presented as means ± SD (n = 4). * p < 0.05 in one-sided student’s t test.