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. 2023 Dec 22;9:467. doi: 10.1038/s41420-023-01755-w

Fig. 4. Proteomic analysis of phosphorylated proteins induced by iCDM-34 treatment.

Fig. 4

A The effect of anti-hepatitis B virus drug; CDM-3008, iCDM-17, iCDM-34 on JAK/STAT signaling. The heatmap illustrates the phosphorylation state of STAT1 and STAT3, known phosphoproteins stimulated by drug; CDM-3008. The colors represent the log2 ratio of drug versus DMSO. B The effect of CDM-3008, iCDM-17, iCDM-34 on JAK/STAT signaling was confirmed by Western blotting. Phosphorylation of STAT1, STAT2, STAT3 was analyzed after the 24 h of treatments with 30 μM CDM-3008, iCDM-17, and iCDM-34. C Top 15 biological functions altered by iCDM-34 treatment. The bars are corresponding to z-scores; the positive or negative z-score values indicate a function that was predicted to be increased or decreased by CDM-3008 (Green), iCDM-17 (Pink) and iCDM-34 (Blue). The dash lines represent the z-score = 2 (red dash) or = −2 (blue dash). The z-score greater than 2 or smaller than -2 can be considered significant altered. All the biological functions are significant (p-value ≤ 0.05). The lower panel heatmap shows the phosphoproteins involved in “Replication of virus”, which were specifically decreased by iCDM-34. The colors represent the log2 ratio of drug versus DMSO.