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. 2023 Dec 22;9:467. doi: 10.1038/s41420-023-01755-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Activation of AhR signaling pathway in 3D cultured FLC-4 cells. 3D cultured FLC-4 cells were treated with 0, 1, 10 μM iCDM-34 for 1 day. CYP1A2 (blue bars), CYP2C9 (orange bars), and CYP3A4 (gray bars) mRNA expression levels were measured by quantitative PCR. Error bars indicate SD (n = 3). B HepG2-NTCP-C4 cells were treated with 30 μM iCDM-17 and iCDM-34 for 1 day. Expression levels of phospho-SAMHD1, SAMHD1, and β-actin were analyzed by Western blotting. C–H HepG2-NTCP-C4 cells were treated with 30 μM iCDM-17 and iCDM-34 for 3, 8, 24 h. Expression levels of CDK1 (C–E) and CDK2 (F–H) mRNA were analyzed by qPCR. Error bars indicate SD (n = 3). The data are presented as means ± SD. *p < 0.05 and **p < 0.01 in two-tailed student’s t test.