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. 2023 Sep 29;27(24):3966–3973. doi: 10.1111/jcmm.17978

TABLE 1.

Summary of studies which assessed expression, function, and regulatory mechanisms of SAMMSON in different types of cancers

Cancer type Clinical samples Assessed cell lines SAMMSON expression Effects: in vitro and in vivo Regulatory mechanism Ref

Melanoma

 67 malignant melanoma and 11 nevi tissues SK‐MEL‐110, A375, A875, SK‐MEL‐28, and M21, ACHN, CaKi‐1, 786‐O, HaCaT UP ▼ SAMMSON: ↓cell proliferation, ↓invasion, ↓migration SAMMSON /EZH2/H3K27me3/ FOXA2 17
‐ A375, HEK293FT, 1205Lu, A375 TR, 1205Lu TR, SK‐MEL‐28 UP ▼ SAMMSON: Activated p53 signalling, Sensitized melanoma cells to RAF inhibitor, ↑ rate of apoptosis SAMMSON/CARF/p53 10
‐ SK‐MEL‐28, SKMEL‐28, LCLs, Mel‐ST, HEK293T, NHEM, MM UP ∆ SAMMSON: ↑ Cell growth, ↑ protein synthesis SAMMSON/ CARF/XRN2/p32 22

Uveal melanoma

 21 Paired tissues 92–1, OMM1, OMM2.3, MEL270, MP38, MP46, MM28, MP65, CRMM1, CRMM2, MEL077, SK‐MEL28, HEK293T, CT5.3hTERT UP

▼ SAMMSON: ↓Growth, ↓Cell viability, ↑Apoptosis,

↓mitochondrial function

 SAMMSON/p32 15

BC

 68 TNBC Paired tissues HCC70 and BT‐549 UP ∆ SAMMSON: ↑Cell proliferation SAMMSON/p53 23
‐ MCF‐7, MCF‐7dox UP ▼ SAMMSON:↓Chemoresistance, ↓glycolytic metabolism, ↓ROS production metabolic rewiring with improvement of oxidative metabolism 11
GC 126 Paired tissues SGC‐7901, HCG‐27, AGS, MGC803 UP ▼ SAMMSON: ↓invasion, ↓migration ‐ 24

HCC

 70 Paired tissues SNU‐182, SNU‐398 UP ∆ SAMMSON: ↑invasion, ↑migration SAMMSON/miR‐9‐3p 13
19 peri‐tumour, 7 early HCC and 12 aHCC samples 293 T UP ∆ SAMMSON: ↑liver TIC self‐renewal, ↑tumour propagation, ↑invasion SAMMSON/EZH2/ CTNNBIP1/ Wnt/β‐ catenin pathway 25

GBM

 19 Paired tissues U87MG, T98G, U251, LN229, A172, NHA UP ▼ SAMMSON: SAMMSON/PI3K/Akt 12
56 GBM, and 35 control U87, U‐373 MG UP ∆ SAMMSON: ↑ cell proliferation SAMMSON/ miR‐622 26
PTC 70 Paired tissues PC‐1, HTH83, K1, 8505C, SW1736, BCPAP, Nthy‐ori 3–1 UP ▼ SAMMSON: ↓cell proliferation, ↓invasion, ↓tumorigenicity, ↓metastasis SAMMSON/ p300/Sp1 27

Abbreviations: BC, breast cancer, GBM, glioblastoma, GC, gastric cancer, HCC, hepatocellular carcinoma, PTC, papillary thyroid carcinoma, ∆, over‐expression, ▼, knockdown, ↑, increase, ↓, decrease.